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I have read this website and it seems, for whatever reason, a bit more promising than other suggestions. I have been taking 4000 IU of Vitamin D3 per day and 1000mg of Vitamin C per day since April 20th, and have not gotten any substantial cold sores (I did get a small one that lasted two days on May 3rd). Prior to April 20th, I was getting at least one per week. Obviously I need more time to get a more thorough evaluation, and I'm looking forward to the 3-month mark (on July 20th) when apparently my Vitamin D levels should be consistently high enough. I'll keep you updated.
It has now been just over two months since I began following this program (4000 IU of Vitamin D3, 500mg of Vitamin C) and I cannot tell you how happy I am. Seriously, I owe the author of this article such a humongous gratitude. I am exceptionally insecure when I have a cold sore, and since I've followed this regiment I have not gotten a single one. I've been so happy as a result of this. I think these details should be spread around more.
Thank you again to the author of this article. I'm eternally indebted to you.
Good news. When sores do arise they will probably be smaller and shorter lived, but I am confident they will be less frequent now that your immune system is supercharged. Adequate sleep and avoiding undue stress will also help.
It's been over 4 months now and I have not had one single cold sore - prior to following this program, I had never gone more than a few weeks without having one. As a result, my overall happiness has been way up. Again, I'm indebted to you.
I have two questions though - I've been taking the 4000 IU of Vitamin D and 500mg of Vitamin C every day for 4 months. Recently, I began taking 5000 IU of Vitamin D (only because all the store sold were the 5000 caplets) - do you think this is going to affect anything? Is too much Vitamin D bad?
My second question is since you mentioned that after roughly 3 months, your Vitamin D levels should be at 49mL - so, do I continue taking the Vitamin D and Vitamin C the same way I have been? Or do I cut it short lest my Vitamin D blood levels go higher? If you could please clarify/elaborate on this for me I would greatly appreciate it, and I will be sure to keep you updated.
Further, considering how drastically this program has helped me and ultimately changed my life, I'm going to suggest this website to others on other cold sore forums to help them.
Thank you again for everything.
If you are tolerating 5000 IU well then you are most likely fine. As of a couple of years ago, no cases of vitamin D toxicity had ever been reported in people taking under 10,0000 IU. You are taking half that amount. A lot of people with Multiple Sclerosis take 10,000 IU per day to reduce inflammation. I know a cardiologist who gives his patients 50,000 IU pills to be taken once a week. That averages out to about 7000 IU per day. If you are healthy, I see no reason to take more than 5000 IU. If you are still concerned you could try skipping a couple times a week now and then.
The prefered upper levels of serum levels of Vitamin D are still open for debate. Recent research suggests that acceptable upper levels can go quiet a bit higher than levels required to sustain normal health.
Check your levels with your doc if you are concerned.
I once posted this website information in a herpes cold sore forum. The website administrators banned me and my post. I guess they thought I was spamming. Kind of sad, really.
You are welcome.
I have updated the Vitamin D levels section. Vitamin D is measured by blood 25(OH)D levels. Make sure that your 25(OH)D levels are below 100 ng/ml. According to the Vitamin D Council, levels over 100 ng/ml are difficult to reach if you stay under 10,000 IU per day and do not get a lot of sun. To be safe you could ask for a Vitamin D level check the next time you see a doctor after a few months of continuous dosing, or reduce your dose by skipping days or taking 2000 IU of Vitamin D3 per day.
Thank you for this! And thank you again for all your help! The past 4-5 months have been some of the happiest of my life because I've been able to live my life *uninterrupted* by a recurring, embarrassing virus.
I will be seeing my doctor soon and following up on all of this.
I, too, tried advertising this website on a few cold sores forums only out of my genuine desire to help others who suffer from these as well. I felt it was the least I could do to give back. Not sure how many people followed up though. In any case, I firmly believe that this research needs to be more widespread among the medical community as it can help countless others like me who suffered from this!
Thank you for the information on vitamin D. I have been plagued with Cold Sores for many years. I often use Zovirax once I feel the sore start to pop up. But even with this drug if you don't catch it right away you will get stung with a nasty cold sore. Looking forward to trying your regimen.
My mom was recently diagnosed with cancer. While sitting in the hospital with her I read an ebook on Vitamin D3 to boost the immune system and help with cancer prevention. The content is right in line with your site. (I'm not promoting it, so feel free to remove the information from my comments but the author is Jeff Bowles $2.99 on Amazon Kindle. He also says its imperative to take Vit K2 while taking high Vit D3 doses to combat what doctors are calling toxicity issues, but its actually that high doses of VD3 cause a depletion of Vit K etc).
My immune system has always been half asleep. If I get a hang nail my entire finger gets red and inflamed. I have been getting cold sores since I can remember. For the last few years I feel like I'm getting them every other week. I've been taking Ayclovir every day for prevention.
When I read the ebook on Vit D3 I got very excited but because it seems like everything is a HS1 trigger for me I decided to do a search on "Vitamin D3 and cold sores". There were several results (the majority) of people saying Vit D was CAUSING cold sores. Some answered that it stood to reason that if the sun could trigger cold sores that Vit D may actually be the sun trigger itself. My first thought was - noooooo! Because I really wanted to find something to boost my immune system and help control the HS1 outbreaks. I decided to do one last search tonight before I gave up on the idea and found your page and was excited when I read the comments where it seems that people are having success.
Have you had anyone comment that they have experienced the opposite and are actually getting more cold sores? If so did they confirm that it was D3 and not D1 or D2? I'm trying to rationalize why D3 wouldn't work...
Can you please keep me updated on positive feedback from people who have seen a difference? I am so hopeful. HS1 has been devastating for me.
Thank you so much!
Sorry to hear about your mother getting cancer. I wish the best for her and your family.
I have not read about VitK2 problems in the literature, but will check it out.
Comments on how well this approach works have been rare. I don't know if people are finding this site, are trying the approach, and I don't know much about how well it is working for people who give it a try. In the 2 years this site has been up I’ve heard back from one person in the comments section.
I have a *very* hard time believing that Vitamin D3 causes outbreaks. Perhaps in a small few, but this would be an exception. The explanation could be something like taking VitD3 along with high levels of calcium that is derived from shellfish. Shellfish is known to contain high amounts of agranine which is linked to HSV-1 outbreaks. One could mistakenly attribute increased cold sore outbreaks to the VitD3 when it is actually the shellfish-based calcium.
Maybe the Vit D supplement itself contains substances that can contribute to outbreaks. I've verified, almost, that sucralose is a trigger for me, if consumed regularly and/or large amounts. I've found this ingredient in some chewable vitamins. Other factors could be the diet of the person taking vit D.. maybe they consumed large amounts of arginine and/or negligible amounts of lysine. This ratio is important to keep hsv in check. In fact, I never had an hsv outbreak until I started consuming large amounts of almonds, which are high in arginine. Minimizing nuts and/or increasing daily (lysine) consumption has reduced the frequency of outbreaks. Without knowing what foods were consumed, or other lifestyle/environmental factors a person is exposed to, it's hard to identify Vit D as a trigger. Vit D may not be very effective if one were to consume large amounts of nuts in the sun, while under significant stress.
Another supplement to consider is Lysine. It's possibly effective for prevention, but definitely helps a bit if taken during the start of an outbreak. Lysine interferes with the hsv ability to reproduce, while Arginine is necessary for reproduction...from what I've read. These are just amino acids (protein building blocks) and can be purchased cheaply over the counter (near the vitamin D). I try to take 2 grams 3-4 times a day during an outbreak... but now I will add Vit D as a preventative measure, and large amounts, along with Lysine during an outbreak.
Finally, I read one more article on cimetidine (Tagamet) that may be helpful. I wouldn't take this as a preventative measure, but if taken at the beginning of an outbreak, it could be helpful. Although this is typically used for heartburn, cimetidine apparently can stimulate the immune system. http://www.lef.org/magazine/mag2001/mar2001_report_tagamet_1.htm
Dave, what is your opinion of cimetidine?
I think you are spot on in your assessment of food high in agrinine. Someone taking VitD3 may also be consuming lots of nuts and/or supplements high in agrinine like Glucosamine-Chondroitin. Under these circumstances it may be difficult to know if VitD3 is helping - in some cases it may seem like VitD3 is making things worse due to a high agrinine diet. I have heard about Lysine but have not yet formed an opinion on its benefits. Lysine might be worth trying for some people. I have not heard about cimetidine boosting innate immunity. I will look into it though. Cheers. - DC
Hi I’m a little confused the tablets on sale here in the UK are only 25 ug see this link ( http://www.hollandandbarrett.com/pages/product_detail.asp?pid=826&prodid=886&cid=163 ) no way near the 2000ug you recommend. Have I misunderstood the dose?
Oh PS thanks for the great website
"ug" (micrograms) is a different dosing system than international units (IU). Check online calculators for converting ug to IU like this one at
Here is what I've read:
To convert IU to micrograms, use "IU * 0.025 = micrograms"
400 IU * 0.025 = 10 ug.
2000 IU * 0.025 = 50 ug
To convert micrograms to IU, use "micrograms/0.025 = IU"
10 ug/0.025 = 400 IU
25 ug/0.025 = 1000 IU (the 25 ug you've seen equals 1000 IU)
50 ug/0.025 = 2000 IU
If someone wanted to take 2000 IU of Vitamin D3, she could take 50 micrograms per day. If someone wanted to take 4000 IU of Vitamins D3, she could take 100 micrograms per day.
Hope this helps.
Oh I see thank you so so much, you don’t know what a help this is, off to my local pharmacy to see if this will help. Thanks for your webpage so balanced and yet supportive.
Thanks for the great info and research you have on this site, I found it very interesting and helpful. I also think innate immune system plays a key role in controlling HSV. Actually my dad had the first HSV outbreak of his life when he was going through cancer treatments where his immunity was basically shut down for a couple of weeks. He had never had a single blister in his life where as my mother has cold sores regularly. So his immune system was able to totally suppress the virus when it was functioning normally.
I think you should be able to supercharge your immune system to a point where you would not even be shedding the virus. As I am suffering from both oral and genital herpes this is something that I'm aiming at so I would reduce the risk of my partners getting infected.
I think you are on the right track with your research so please keep it up!
Well it’s been two months since I started taking VD3 and its been fantastic, not one tingle not one CS. THANK YOU! Can i ask if its safe to keep this dose up indefinably, and if that’s what I need to do?
A constant supply of VD3 is necessary to supercharge the innate immune system. Fortunately VD3 is relative inexpensive and continual dosing at higher appropriate levels does not appear to have any adverse health effects.
If I were to donate several bottles of Vitamin D3 to the author of this blog, plus link to the site from a related site, would you consider linking the term Vitamin D3 to one of my sites on that particular topic? Please email me if interested.
Please post questions and comments on this page.
Prevent Cold Sores